Hereditary neuropathy with liability to pressure palsies (HNPP) is Sound Machine an autosomal neuropathy that is commonly caused by a reciprocal 1.5 Mb deletion on chromosome 17p11.2, at the site of the peripheral myelin protein 22 (PMP22) gene.Other patients with similar phenotypes have been shown to harbor point mutations or small deletions, alth
Summary: Background: Sensitivity has been a key issue for Enhancer of zeste homolog 2 (EZH2) inhibitors in cancer therapy.The EZH2 inhibitor EPZ-6438 was first approved by the US Food and Drug Administration (FDA) in 2020.However, its inadequate anti-cancer activity in solid tumors limits its clinical application.In this study, we utilized the mult
Introduction: Single-station N2 (ssN2) versus multi-station N2 has been used as a selection criterion for treatment recommendations between surgical versus non-surgical multimodality treatment in stage III-N2 NSCLC.We hypothesized that clinical staging would be susceptible to upstaging on pathologic staging and, therefore, challenge this practice.M
Cryptolestes ferrugineus, the Oven Fan Blade rusty grain beetle, is a cosmopolitan pest that has adapted to cool and warm climates due to its unique biology, ecology, and behavior.The rusty grain beetle is a pest of high economic importance; hence, understanding their biology, ecology, and behavior could be useful in designing effective management
Abstract Background Colorectal cancer (CRC) presents a complex tumor microenvironment influenced by genetic and microbial factors.Microbial DNA from the gut and tumor microenvironment can translocate into the bloodstream, forming a circulating microbiome associated with prognosis and clinicopathological features.This study investigates the peripher